The issue of weight gain resulted from the non-control of 2 complementary parameters: excessive caloric intake and/or inadequate energy expenditure. To address the issue, FYTEXIA® designed SINETROL® as a unique, Mediterranean weight-loss ingredient; the proprietary formula provides clinically proven enhancement of lipolysis, helping in body weight management.
The results of 3 previous published clinical studies in a total of 115 adults demonstrate the benefits of SINETROL® for improving the shape of the silhouette and significantly lowering excess body fat. The results also strengthen the evidence for the efficacy of the product in the prevention of metabolic disorders associated with overweight and obesity.
This white paper reveals the results of an ex vivo investigation on adipocytes from humans in tests designed to provide additional understanding of the mechanistic action of SINETROL®, based on the selection of natural citrus fruits extracts of orange (Citrus sinensis L.) and grapefruit (Citrus paradisi Macfad.), in association with an extract of guarana (Paullinia cupana Kunth). This unique combination potentiates the effect of each ingredient to enhance lipolytic activity and antioxidant protection. The demonstrated synergy of these polyphenol-rich ingredients provides increased evidence of their potential in weight management.